Actualités

Dnas le cadre du COST NUtRedOx, un article intitulé "Personalized nutrition in aging society: redox control of major-age related diseases through the NutRedOx Network (COST Action CA16112)" vient d'être publié dans "Free Radical Research".

Auteurs : Josep Tur, Claus Jacob, Patrick Chaimbault, Mohammad Tadayyon, Elke Richling, Nina Hermans, Claudia Nunes dos Santos, Marc Diederich, Linda Giblin, Mourad Elhabiri, Caroline Gaucher, Pierre Andreoletti, Ana Fernandes, Michael Davies, Agnieszka Bartoszek, Mustapha Cherkaoui-Malki

Lien vers l'article : https://www.tandfonline.com/doi/abs/10.1080/10715762.2019.1572890

Doi: 10.1080/10715762.2019.1572890

Abstract

A healthy ageing process is important when it is considered that one third of the population of Europe is already over 50 years old, although there are regional variations. This proportion is likely to increase in the future, and maintenance of vitality at older age is not only an important measure of quality of life but also key to participation and productivity. So, the binomial "nutrition and ageing" has different aspects and poses considerable challenges, providing a fertile ground for research and networks. The NutRedOx network will focus on the impact of redox active compounds in food on healthy ageing, chemoprevention and redox control in the context of major age-related diseases. The main aim of the NutRedOx network is to gather experts from Europe, and neighboring countries, and from different disciplines that are involved in the study of biological redox active food components and are relevant to the ageing organism, its health, function and vulnerability to disease. Together, these experts will form a major and sustainable EU-wide cluster in form of the NutRedOx Centre of Excellence able to address the topic from different perspectives, with the long-term aim to provide a scientific basis for improved nutritional and lifestyle habits, to train the next generation of multidisciplinary researchers in this field, to raise awareness of such habits among the wider population, and also to engage with industry to develop age-adequate foods and medicines.

A doctoral position (cosupervision France/Germany) is open for September/october 2019, with LUE funding. Applications are open until 30 April 2019.

Titre :  Novel organoselenium coumpounds: From the heart of the tuna fish to antioxidant capacity via intricate nitric oxide signaling - SeleNOx

In recent years, a particular interest has been given to organoselenium compounds as antioxidants. Organoselenium compounds are often “natural”, found, for instance, as selenoneine in tuna, or as selenoproteins, such as the glutathione peroxidases and thioredoxin reductases, in mammals. Ebselen, the flagship of biologically active organoselenium compounds, is currently being investigated in clinical trials. From a physiological perspective, the ability of selenium to catalyse the release of nitric oxide (NO) from S-nitrosothiols (RSNOs), has been shown with ebselen derivatives covering medical devices that exhibited antithrombotic properties. This PhD project will exploit our knowledge on selenocompounds and S-nitrosothiols to elucidate the antioxidant and catalytic mechanisms of selenocompounds releasing NO from RSNOs to improve vasodilation and physiological NO storage in blood vessels. These properties will emphasize the synergy between these two types of compounds and open new potentials for applications in cardiovascular diseases.

More details in the pdf file below.

Un article intitulé "Long-lasting and controlled antioxidant property of immobilized gold nanoparticles for intelligent packaging" vient d'être publié dans "Colloids and Surfaces B : Biointerfaces"

Auteurs : Jordan Beurton, Igor Clarot, Julie Stein, Benjamin Creusot, Christophe Marcic, Eric Marchioni, Ariane Boudier.

Lien vers l'article : https://doi.org/10.1016/j.colsurfb.2019.01.030

DOI : 10.1016/j.colsurfb.2019.01.030

Abstract

The development of new packaging able to preserve sensitive biomolecules against oxidative stress is an important field. Several studies refer to antioxidant properties carried out by colloidal gold nanoparticles (AuNP). Herein, the purpose was to check whether this property is preserved when AuNP are immobilized on a glass support. After nanostructured film preparation, the physicochemical characterization proved that AuNP were well-individualized in the films with a high density of immobilization. Two radicals: ABTS^•+ and DPPH^• were used to investigate their antioxidant capacity. The results showed that immobilized AuNP had a preserved antioxidant capacity characterized by a different kinetic: more controlled and more prolonged but with the same efficiency (vs the same quantity of colloidal AuNP). The AuNP films demonstrated a capacity to prevent from degradation a molecule containing a thiol function. A 10-fold increase of N-acetylcysteine half-life was measured using the immobilized AuNP, highlighting the interest of the developed and adaptable support.

Un article intitulé "Nanotechnologies for medical devices: potentialities and risks" vient d'être publié dans "ACS Applied Bio Materials"

Auteurs : Arnaud Pallotta, Igor Clarot, Jonathan Sobocinski, Elias Fattal, Ariane Boudier.

Lien vers l'article : https://pubs.acs.org/doi/10.1021/acsabm.8b00612

DOI: 10.1021/acsabm.8b00612

Abstract

Many novel medical devices (implantable or not) include nanomaterials through either surface-coating by nanoparticles or by direct nanostructuration of the surface. In this review, we have identified several medical devices currently on the market in various health domains (wound healing, prevention or treatment of infectious diseases, cardio-vascular diseases, organ or joint replacement, and finally medical devices associated with nanomedicines). The very peculiar physicochemical characterization of the nanostructured medical devices is described. Keys to understand their possible interaction with the organism (positive or negative via toxicity) are given. Finally, as a conclusion, we discuss the specific quality control as well as the regulatory issues arising from the lack of regulation for approving nanomaterial combining medical devices.

Un artcile intitulé "Nanoparticules dans les médicaments : comment assurer le contrôle qualité" vient d'être publié dans "The Conversation"

Auteurs : CLAROT Igor, BOUDIER Ariane, PALLOTTA Arnaud

Lien vers l'article : http://theconversation.com/nanoparticules-dans-les-medicaments-comment-assurer-le-controle-qualite-108481

Les 19 et 20 décembre prochains, deux professeurs de l'EA donneront des conférences invitées à l'Université Ibn Tofail à Kénitra, au Maroc.

Pierre Leroy : Impact des nanomatériaux en biologie et santé : lien avec le stress oxydant

Igor Clarot : Nanomatériaux en biologie et santé : applications et caractérisations physicochimiques

Mr Clarot donne une conférence invitée au congrès SFNano, à Montpellier, intitulée " Are nanoparticles conventional pharmaceutic raw materials?"

Dans le cadre du projet IMODE (Innovative Multicomponent Drug Design), Ariane Boudier donnera une conférence invitée à Lille le 4 décembre prochain.

La conférence est intitulée "Nanostructured materials: the next generation of active stent".

Le 10 novembre dernier lors de la Cérmonie des Serments, Arnaud Pallotta a reçu le prix de la Faculté de Pharmacie de Nancy pour sa thèse de doctorat d'Université intitulée "Films polymériques pour le développement de stents innovants", dirigée par Igor Clarot et Ariane Boudier.

La première publication matérialisant notre collaboration avec l'équipe de Claus Jacob (Université de la Saare, Sarrebruck, Allemagne) vient d'être accepté dans MedChemComm.

Flush with a flash: Natural three-component antimicrobial agent based on S-nitrosothiols, controlled superoxide formation and “domino” reactions leading to peroxynitrite production. MedChemCommun, in press.

Auteurs : R Alhasan, A Y Abdin, M J Nasim, C E.C.C. Ejike, J Bonetti, P Giummelli, P Leroy, C Gaucher, C Jacob.

Abstract : S-Nitrosothiols are ●NO releasing agents renowned for vasodilatory and antioxidant properties. O2●- promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO-). Since the production of O2●- can be controlled by enzymes or by visible light, such otherwise harmless components can be turned into effective antimicrobial and nematicidal combinations with numerous potential applications in Medicine.