La première publication matérialisant notre collaboration avec l'équipe de Claus Jacob (Université de la Saare, Sarrebruck, Allemagne) vient d'être accepté dans MedChemComm.
Flush with a flash: Natural three-component antimicrobial agent based on S-nitrosothiols, controlled superoxide formation and “domino” reactions leading to peroxynitrite production. MedChemCommun, in press.
Auteurs : R Alhasan, A Y Abdin, M J Nasim, C E.C.C. Ejike, J Bonetti, P Giummelli, P Leroy, C Gaucher, C Jacob.
Abstract : S-Nitrosothiols are ●NO releasing agents renowned for vasodilatory and antioxidant properties. O2●- promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO-). Since the production of O2●- can be controlled by enzymes or by visible light, such otherwise harmless components can be turned into effective antimicrobial and nematicidal combinations with numerous potential applications in Medicine.