Conférence du Dr Amedea B Seabra du Center for Natural and Human Sciences Federal University of ABC (Brésil) le 15 juin à la Faculté de Pharmacie de Nancy
"Nitric oxide releasing biomaterials for biomedical and agricultural applications"
The free radical nitric oxide (NO) plays a key role in several biological processes in mammals, such as the control of vasodilation, the immunological responses, the inhibition of platelet adhesion, the cell communication, anti-cancer activities, and the wound healing. In addition, NO is recognized as important molecule in several physiologic process in plants, including break seed dormancy, stimulate plant germination and greening, control iron homeostasis in plants, and improve plant tolerance to salinity, metal toxicity, temperature and drought stress. As a free radical, NO donors are administrated in several applications. Among them, S-nitrosothiols (RSNOs) are an important class of NO donors, since they spontaneously decompose releasing NO, and this decomposition can be triggered by light irradiation (visible region). Several papers in the literature reveal that the combination of nanotechnology and RSNOs is a promising strategy to allow the therapeutic uses of NO. In this context, this presentation focuses on the synthesis strategies, characterization, in vitro and in vivo applications of NO-based metallic and polymeric nanoparticles, hydrogels and films for biomedical and agriculture applications.